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Further, animal studies have shown that there is an increase in Nrf2 expression, increasing the expression of antioxidant enzymes after acute (Muthusamy et al., 2012) and chronic PE (Gounder et al., 2012)

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Metabolism Runs on Microbial Signals, Not Just Calories The gut microbiome generates molecules that communicate directly with metabolism

This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)